Intersubunit conformational changes mediate epithelial sodium channel gating
نویسندگان
چکیده
منابع مشابه
Intersubunit conformational changes mediate epithelial sodium channel gating
The epithelial Na(+) channel (ENaC) functions as a pathway for Na(+) absorption in the kidney and lung, where it is crucial for Na(+) homeostasis and blood pressure regulation. However, the basic mechanisms that control ENaC gating are poorly understood. Here we define a role in gating for residues forming interfaces between the extracellular domains of the three ENaC subunits. Using cysteine s...
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ژورنال
عنوان ژورنال: Journal of General Physiology
سال: 2014
ISSN: 1540-7748,0022-1295
DOI: 10.1085/jgp.201411208